While maybe Wx takes a bit of getting used to, it has allowed me to create a sophisticated application with a sophisticated interface faster than I would have otherwise been able to. Add to that, Perl is the 'Glue' that allows me simultaneously to access a variety of c-based apps such as multi-media, prolog, database, email and so on all in utf8, without leaving the security of my single Perl IDE.
I agree that the doc is not as all-encompassing as it might be, but you find it if you look and the user lists wx-users on googlegroups and wxperl-users on perl dot org are great support vehicles and much less strict about on/off topic than some others.
Finally, Padre, another cpan module and IDE is also written in Wx::Perl. Check it out.